ABSTRACT
Background: Lichen planus (LP) is a non-infectious cutaneous disease, characterized by the presence of itchy, flat from top, polygonal, and papular lesions having a strikingly violaceous color. Objectives: The objectives are as follows: (1) To establish the association of hepatitis B and hepatitis C with LP in urban areas of Ajmer and (2) to analyze the derangements in liver function tests of LP patients who attended the outpatient Department of Dermatology in JLN Hospital Ajmer. Materials and Methods: To conduct the study, 102 patients of LP and 100 control subjects were selected between age groups of 18 and 60 years. A detailed history including age, sex, race, residence, clinical symptoms, and their duration was recorded. Control group was selected from blood donors at blood bank of Jawaharlal Nehru Medical College, Ajmer, and was corresponding in age and sex to those of study group. A thorough clinical examination, systemic and cutaneous examination was performed. Clinical findings classical of LP and lesions confirmed histopathologically were used to establish the diagnosis of LP. A rapid test kit was used for detecting seropositivity for hepatitis B virus (HBV) and hepatitis C virus (HCV). Chi-square test and multivariate regression analysis using SPSS version 16 were used to analyze the collected research data. Results: None of the patients of LP in the study group were HCV and HBV positive. None of the control group was positive for both viral infections. In 16 patients (15.68%), the levels of serum aspartate aminotransferase were beyond the normal limits, and higher levels of alanine aminotransferase were detected in 5 patients (4.90%). Bilirubin concentrations higher than the normal limits were detected in total 16 patients (15.68%). Conclusion: No association of hepatitis B and C with LP could be established from the present study. More detailed research is needed to establish the correlation between hepatitis B and C and LP.
ABSTRACT
Background: Transplantation of autologous non-cultured epidermal cell suspension containing melanocytes (ANEM) is one of the well-known surgical options for repigmenting stable vitiligo lesions. The recipient site for transplantation has traditionally been prepared by dermabrasion, liquid N2, or laser resurfacing, which is costly, cumbersome and has risk of scarring. Objectives: The objectives of this study were to experiment a novel method of repigmenting stable vitiligo lesions by intraepidermal injection of ANEM in the vitiligo lesions. Materials and Methods: A total of 50 stable vitiligo lesions in 50 patients were included in the study. The prepared ANEM was inoculated intraepidermally in the lesions. Patients were given PUVASOL therapy in post-operative period and followed up 4 weekly for 24 weeks to see repigmentation. Results: At 24 weeks, pigmentation was seen in 31 (62%) lesions of 50 lesions. It was excellent in 6 (12%), good in 10 (20%), satisfactory in 8 (16%), and poor in 7 (14%) patients. Adverse events were mild and insignificant. Conclusion: Intraepidermal ANEM inoculation in stable vitiligo lesions is an effective, safe, and cheap dermatosurgical procedure.
ABSTRACT
In this research a preliminary behavioral evaluation was accomplished with subjects of the species Rattus novergicus submitted since gestation, to microwave radiation in several frequencies during one hour daily...